MED TOPIC: Opioid Rotation in Patients with Cancer Pain
Opioid Rotation in Patients with Cancer Pain. A Retrospective Comparison of Dose Ratios between Methadone, Hydromorphone, and Morphine [Abstract] - Bruera et al., Cancer, 78(4), 852-857, 1996.
Comment (DeLuca):
In this brief abstract the authors present the results of a retrospective series of 48 med changes from morphine to hydromorphone (Dilaudid), and 65 changes between hydromorphone and methadone. Data is given that underscores the need for close clinican observation of the patient over time, and adherence to rational regimens.
See also:
Opiate Rotation, Incomplete Cross-Tolerance, and Hyperalgesic Metabolites – DeLuca; 2001. This was my first attempt at researching and understanding some of these interesting ideas.
Expect an update on this topic and on related recent work on Ultra Low Dose Naltrexone in an upcoming War on Doctors / Pain Crisis feed.
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Tags: statistics, Uncategorized
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